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KMID : 0861120100140020077
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Korean Journal of Oriental Preventive Medicine
2010 Volume.14 No. 2 p.77 ~ p.89
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The Effects of Cuscuta japonica Chois on Gene Expression in RANKL-induced RAW 264.7 Cell
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Kim Joon-Yeon
Hwang Gwi-Seo
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Abstract
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Objectives : This study was performed to evaluate the effect of CJ(Cuscuta japonica Chois) on osteoclast differentiation and gene expression.
Methods : The osteoclastogenesis and gene expression were determined in RANKL(receptor activator of nuclear factor kappa B ligand)－stimulated RAW 264.7. The results were summarized as followes.
Results : CJ decreased the number of TRAP positive cell in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of RANK(receptor activator of nuclear factor kappa B), , and IL-6 in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of iNOS and COX-2 in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of Cathepsin K in RANKL-stimulated RAW264.7 cell.
Conclusions : It is concluded that CJ might decrease the bone resorption resulted from decrease of osteoclast differentiation and it’s related gene expression.
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KEYWORD
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Cuscuta japonica Chois(CJ), RANKL, RANK
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